Provision of information and recommendation by pharmacists regarding drug-related problems in hospitalized dyslipidemia patients: A pre-experimental pre-post design research

Abstract

Dyslipidemia is a condition of imbalance in the lipid profile of the body and a risk factor for atherosclerotic disease. In this context, the administration of statin as the main choice in the therapy has been proven safe. However, the method can cause drug-related problems that affect the effectiveness and safety of treatment. This drug-related problem is reduced and resolved through drug therapy monitoring activities by pharmacists. Therefore, this research aims to describe the characteristics of hospitalized dyslipidemia patients and identify drug-related problems, as well as analyze the effect of providing information and recommendation by pharmacists on changes in the number of statin drug-related problems. This research was conducted with a pre-experimental design before and after the interventions prospectively including 102 hospitalized dyslipidemia patients. Drug therapy monitoring was carried out while patients were hospitalized and the problems were identified using the Indonesian PCNE version 9.00 classification. Additionally, the data obtained were analyzed statistically to determine the effect of providing information and recommendations by pharmacists on changes in the number of drug-related problems. The number of drug-related problems in 102 hospitalized dyslipidemia patients identified and intervened was 307, consisting of 83% safety and 17% effectiveness, respectively. The provision of information by pharmacists had a significant effect (p-value 0.000 <0.05), reducing the number of drug-related problems by 90%. The provision of information and recommendations by pharmacists reduced the number of drug-related problems in hospitalized dyslipidemia patients.