Contribution to the study of the biological activities of pomegranate peel

Abstract

This study investigates the wound-healing efficacy of pomegranate (Punica granatum L.) bark powder, a fruit historically revered for its medicinal properties. Conducted over 14 days using Wistar rats, the research compared a control group, two test groups (treated with 0.5 g and 1 g of powder), and a reference group using a commercial ointment. The experimental design focused on evaluating skin irritation and monitoring macroscopic wound contraction. The results demonstrated that pomegranate bark powder significantly accelerates the healing process without causing skin irritation. Remarkably, treated wounds reached near-complete recovery in approximately four days, a much faster rate than the untreated control group. This enhanced regeneration is attributed to the bark's bioactive compounds, which possess potent antioxidant and regenerative properties. Ultimately, the study concludes that pomegranate bark is a promising natural source for developing pharmaceutical and nutraceutical applications aimed at improving tissue repair and human health.