Investigation of Helicobacter Pylori in patients suffering from stomach ulcer by BABA Gene: Adherence factor

Abstract

To identify the presence of the BabA adhesion gene in patients who are Helicobacter pylori positive and suffering from gastric ulcers and to determine if there is any correlation between its presence and the severity of the ulcers. One hundred patients with diagnosed gastric ulcers were recruited, and each underwent endoscopy to obtain biopsy specimens from their gastric mucosa. The BabA gene was detected using a polymerase chain reaction in which specific primers targeting the gene were utilized. Sixty-five percent of the patients were positive for the BabA gene, and the results were considerably more significant among those with the most severe forms of ulceration. The authors believe that the BabA gene reduces the effectiveness of the mucosal barrier and is thus an essential factor in the development of gastric ulcers. These conclusions underline the significance of genetic testing of the BabA gene in subjects suffering from advanced stages of gastric ulcers, particularly for diagnostic procedures. The results highlight the necessity of studies regarding the BabA gene in clinical settings to mitigate the risk of significant gastric ulcers and improve treatment options.