A library and laboratory research experiment was conducted in 2020 on determination and detection of mineralic and chemical appearances of mineralic gypsum in Karkar and Doodkash of Baghlan Province to determine the amount of gypsum minerals in the stones of the areas, detect the composition of gypsum stones and evaluate the importance of gypsum stone in Baghlan Province. The laboratory results indicated that the percentage of mineralic gypsum in composition of mineralic appearances of gypsum stone in Karkar and Doodkash were 95 percent. Despite the slight presence of some other minerals like Sylvine and Iron minerals in composition of the gypsum stone in both the locations were possible. The analyzed laboratory results by XRF machine revealed that besides of the mentioned elements in composition of mineralic appearances of gypsum stone, the elements such as silicon, iron, potassium, chlorine and aluminum were also present in different percentages. Therefore, it can be concluded that the mineralic appearances of gypsum stones in Karkar and Doodkash are the most important gypsum stone in Baghlan province and it can be used for production of constructional gypsum, Ghori Cement Factory and other similar uses.